Abstract

Creatine Monohydrate, a supplement typically used by Bodybuilders to gain muscle has recently caught the attention of researchers to help mitigate the effects of chemotherapy. Creatine helps build muscle by regenerating adenosine triphosphate which increases muscle size, strength, and power. Researchers are looking at using Creatine monohydrate to mitigate Doxorubicin, a chemotherapy drug. It is currently being tested on MAT B III, an immortal breast cancer cell line in rats, which can be used to model human breast cancer. The end goal of this experiment is having cancer patients taking creatine supplementation. This research is examining how creatine monohydrate effects MAT B3 cell growth dynamics. This is done by first incubating MAT B3 cells and then plating them and splitting them into a control group and a creatine supplemented group. After this is done the platted MAT B3 cells are counted after 1 day, 3 days and 7 days and then the data was compared. Although at the end of the experiment the Creatine group grew more MAT B3 cells than the control,  it is not statistically significant.


Doxorubicin

Doxorubicin is a chemotherapy drug currently being used treat a variety of cancers. It works by disrupting the topoisomerase-2-mediated DNA repair which is why it is used in treatments against solid tumors 

Exercise

  • Exercise has shown to help prevent cardiac dysfunction and cardiotoxicity in rats injects with Doxorubicin​
  • Unfortunately since Doxorubicin increases fatigue it is very hard for patients going through chemo with Doxorubicin to exercise

Creatine 

Creatine Monohydrate, a supplement typically used by Bodybuilders to gain muscle has recently caught the attention of researchers to help mitigate the effects of chemotherapy. Creatine helps build muscle by regenerating adenosine triphosphate which increases muscle size, strength, and power. Researchers are looking at using Creatine monohydrate to mitigate Doxorubicin, a chemotherapy drug

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